Cross-Coupling Reactions of Monosubstituted Tetrazines
نویسندگان
چکیده
A Ag-mediated Pd-catalyzed cross-coupling method for 3-bromo-1,2,4,5-tetrazine with boronic acids is presented. Electronic modification of the 1,1'-bis(diphenylphosphine)ferrocene (dppf) ligand was found to be crucial good turnover. Using this fast method, a variety alkyl-, heteroatom-, and halide-substituted aryl- heteroaryl-tetrazines were prepared (29 examples, up 87% yield).
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c01813